New publication in JACS
Edward Tate’s group at Imperial College London developed a potent and selective activity-based probe for KLK6 (kallikrein-related peptidase), a secreted serine protease with a role in pancreatic cancer. The best probe efficiently reduced invasiveness of pancreatic ductal adenocarcinoma cells that secrete active KLK6. Also, these novel KLK6 probes can be used as a toolset to validate KLK-associated signalling partners across many diseases. Pravin supported this study by determining a range of KLK6 crystal structures with the probes bound.
A KLK6 Activity-Based Probe Reveals a Role for KLK6 Activity in Pancreatic Cancer Cell Invasion
Leran Zhang, Scott Lovell, Elena De Vita, Pravin Kumar Ankush Jagtap, Daniel Lucy, Andrea Goya Grocin, Svend Kjaer, Annabel Borg, Janosch Hennig, Aubry K Miller, Edward W Tate.
J Am Chem Soc 2022 Nov 22.