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Biochemistry IV - Biophysical Chemistry - Prof. Dr. Janosch Hennig

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New publication in Nucleic Acids Research

23.01.2023

In this work, we could show that RNA binding of cold shock domains (CSDs) goes way beyond the typical single domain-RNA contacts. The non-canonical CSDs are involved in direct RNA contacts and at least three domains (CSD789) synergistically bind RNA. Also, we present for the first time a complex structure between poly(A)-binding protein and Upstream-of-N-Ras. Both proteins have been shown to interact during translation initiation. Thus, this work is a major contribution towards understanding regulation of translation initiation.

Upstream of N-Ras C-terminal cold shock domains mediate poly(A) specificity in a novel RNA recognition mode and bind poly(A) binding protein

Nele Merret Hollmann, Pravin Kumar Ankush Jagtap, Johanna-Barbara Linse, Philip Ullmann, Marco Payr, Brice Murciano, Bernd Simon, Jochen S Hub, Janosch Hennig.

Nucleic Acids Res DOI: https://doi.org/10.1093/nar/gkac1277
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