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Biochemistry IV - Biophysical Chemistry - Prof. Dr. Janosch Hennig

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New publication in J Struct Biol

18.11.2022

Here we show that the C domains of the blood coagulation protein von Willebrand factor have consistently two subdomains, which move with respect to each other in nanosecond to millisecond time scales. This is essential for assisting in platelet formation during wound healing. Mutations related to an increased risk in myocardial infarction (heart attack) affect these dynamics.
Structure and dynamics of the von Willebrand Factor C6 domain.
Chen PC, Kutzki F, Mojzisch A, Simon B, Xu ER, Aponte-Santamaría C, Horny K, Jeffries C, Schneppenheim R, Wilmanns M, Brehm MA, Gräter F, Hennig J.


J Struct Biol. 2022 Nov 18:107923.
DOI: https://doi.org/10.1016/j.jsb.2022.107923
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